Maternal exposure to a human based mixture of persistent organic pollutants (POPs) affect gene expression related to brain function in mice offspring hippocampus

Male and female mice pups were exposed to a low high dose of human relevant mixture persistent organic pollutants (POPs) during pregnancy lactation. Most compounds detected in the dams found offspring brains. The exhibited changed expression hippocampal genes involved cognitive function (Adora2a, Auts2, Crlf1, Chrnb2, Gdnf, Gnal, Kcnh3), neuroinflammation (Cd47, Il1a), circadian rhythm (Per1, Clock), redox signalling (Hmox2) aryl hydrocarbon receptor activation (Cyp1b1). A few differentially expressed males versus females. Mostly, similar patterns gene changes observed between groups. Effects on learning memory measured Barnes maze (not moving, escape latency) group when combined with moderate stress exposure (air flow from fan). Mediation analysis indicated adaptation effects since compensated for disabilities (escape latency, walking distance time spent not moving maze). Additionally, random forest that Kcnh3, Crlf1 most important while Hip1, Gnal level explanatory factors passive behaviour moving). Altogether, this study showed transfer POPs brains after maternal exposure, modulating brain function.